Inhaled aerosol dose distribution between proximal bronchi and lung periphery
نویسندگان
چکیده
منابع مشابه
[Distribution of inhaled aerosol using nasal nebulizer].
In this paper, we examined distribution and deposition of inhaled 99mTc aerosols in human respiratory tract, nebulization equipment and expired aerosols. Jet nebulizers were used and aerosols were inhaled through the nose. Results were as follows: 1. On normal breathing, deposition rate of human respiratory tracts in normal subjects were 22% of total dosage and there was no difference from sinu...
متن کاملAerosol antibiotic therapy in suppurative diseases of the lung and bronchi.
Inhalation therapy has become very popular both with physicians and the laity. While the use of antibiotics by nebulization is rather recent, the utilization of germicidal mists and therapeutic gases dates back many years. Those interested in a complete review of the historical background for aerosol therapy should read Segal’s excellent article on the subject.’ The original report on penicilli...
متن کاملInfluence of airway calibre on the intrapulmonary dose and distribution of inhaled aerosol in normal and asthmatic subjects.
We investigated the relationship between airway calibre and the dose and distribution of inhaled aerosol in ten normal and six asthmatic subjects. Subjects inhaled saline aerosol containing 99mTcO4 delivered from a nebulizer connected to a dosimeter, and the lung fields were scanned with a gamma-camera. Right lung dose (RLD) was calculated as percentage of total dose. Intrapulmonary distributio...
متن کاملDry air- and hypertonic aerosol-induced bronchoconstriction and cellular responses in the canine lung periphery.
Dry air and hypertonic saline both create an osmotic stress to the airways, whilst dry air alone induces transient cooling of the airway mucosa. It is unclear whether these two stimuli lead to bronchoconstriction via the same mechanisms. We compared airflow- and hypertonic aerosol-induced bronchoconstriction (AIB and HIB, respectively) in the canine lung periphery, using a wedged bronchoscope t...
متن کاملDistribution of inhaled fluticasone propionate between human lung tissue and serum in vivo.
High retention of inhaled glucocorticoids in the airways means prolonged anti-inflammatory action and low delivery into the serum. The objective of this study was to investigate the retention in and distribution of inhaled fluticasone propionate (FP) between central and peripheral human lung tissue and serum in vivo. In 17 patients undergoing lung resection surgery, a single 1.0 mg dose of FP w...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Pharmaceutics and Biopharmaceutics
سال: 2020
ISSN: 0939-6411
DOI: 10.1016/j.ejpb.2020.04.019